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E-BOOK

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Title	Erythropoietins and Erythropoiesis : Molecular, Cellular, Preclinical, and Clinical Biology / edited by Graham Molineux, Mary Ann Foote, Steven G. Elliott.
OCLC	978-3-7643-7543-0
ISBN	9783764375430
ISBN/ISSN	10.1007/3-7643-7543-4 doi
Publisher	Basel : Birkh�user Basel, 2006.
Description	XII, 270 pages : online resource.
	text file PDF rda
LC Subject heading/s	Medicine.
	Pharmacology.
	Endocrinology.
	Sports medicine.
	Cytology.
Other Subject heading/s	Biomedicine.
	Pharmacology/Toxicology.
	Cell Biology.
	Sports Medicine.
	Endocrinology.
Contents	Background and basic science -- Erythropoiesis: an overview -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin -- Structural basis for the signal transduction of erythropoietin -- Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues -- Erythropoietin receptor signaling processes -- Clinical pharmacokinetic properties of rHuEPO: a review -- Biology of erythropoietin -- Commercial production of recombinant erythropoietins -- Clinical use of recombinant erythropoietins -- Use of recombinant erythropoietins in the setting of renal disease -- Erythropoietic therapy in the practice of oncology -- Use of recombinant erythropoietins for the treatment of anemia of chronic disease -- Use of erythropoietins in the surgical setting -- Abuse of recombinant erythropoietins by athletes -- Antibodies to endogenous and recombinant erythropoietin -- New molecules and formulations of recombinant human erythropoietin.
Summary	Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

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ISBN	9783764375430
ISBN/ISSN	10.1007/3-7643-7543-4 doi
Title	Erythropoietins and Erythropoiesis : Molecular, Cellular, Preclinical, and Clinical Biology / edited by Graham Molineux, Mary Ann Foote, Steven G. Elliott.
Publisher	Basel : Birkh�user Basel, 2006.

Title

Erythropoietins and Erythropoiesis : Molecular, Cellular, Preclinical, and Clinical Biology / edited by Graham Molineux, Mary Ann Foote, Steven G. Elliott.

ISBN	9783764375430
ISBN/ISSN	10.1007/3-7643-7543-4 doi

Description	XII, 270 pages : online resource.
	text file PDF rda

OCLC	978-3-7643-7543-0

Publisher

Basel : Birkh�user Basel, 2006.

Contents

Background and basic science -- Erythropoiesis: an overview -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin -- Structural basis for the signal transduction of erythropoietin -- Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues -- Erythropoietin receptor signaling processes -- Clinical pharmacokinetic properties of rHuEPO: a review -- Biology of erythropoietin -- Commercial production of recombinant erythropoietins -- Clinical use of recombinant erythropoietins -- Use of recombinant erythropoietins in the setting of renal disease -- Erythropoietic therapy in the practice of oncology -- Use of recombinant erythropoietins for the treatment of anemia of chronic disease -- Use of erythropoietins in the surgical setting -- Abuse of recombinant erythropoietins by athletes -- Antibodies to endogenous and recombinant erythropoietin -- New molecules and formulations of recombinant human erythropoietin.

Summary

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

E-BOOK